Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
C. Sturchler-Pierrat,,D. Abramowski,13 Authors,B. Sommer
1997 · DOI: 10.1073/PNAS.94.24.13287
Proceedings of the National Academy of Sciences of the United States of America · 1,552 Citations
TLDR
These mice resemble major features of AD pathology and suggest a central role of A beta in the pathogenesis of the disease.