Triglycerides induce leptin resistance at the blood-brain barrier.
Triglycerides induce leptin resistance at the blood-brain barrier.
W. Banks,Alan B. Coon,4 Authors,J. Morley
2004 · DOI: 10.2337/DIABETES.53.5.1253
Diabetes · 510 Citations
TLDR
It is shown that milk, for which fats are 98% triglycerides, immediately inhibited leptin transport as assessed with in vivo, in vitro, and in situ models of the BBB, and suggested that triglyceride-mediated leptin resistance may have evolved as an anti-anorectic mechanism during starvation.