Tracking a complete voltage-sensor cycle with metal-ion bridges
Tracking a complete voltage-sensor cycle with metal-ion bridges
Ulrike Henrion,Jakob Renhorn,6 Authors,F. Elinder
2012 · DOI: 10.1073/pnas.1116938109
Proceedings of the National Academy of Sciences of the United States of America · 145 Citations
TLDR
The results provide molecular insight into the transition, suggesting that S4 slides at least 12 Å along its axis to open the channel with a 310 helix region present that moves in sequence in S4 in order to occupy the same position in space opposite F290 from open through the three first closed states.