Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.
Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms.
B. Hou,B. Reizis,A. DeFranco
2008 · DOI: 10.1016/j.immuni.2008.05.016
Immunity · 390 Citations
TLDR
The generation of mice selectively lacking the crucial TLR-signaling adaptor MyD88 in dendritic cells is reported, demonstrating that DCs and other innate immune cells can respond via TLRs and collaborate in promoting Th1 adaptive immune responses to an aggregated stimulus.