Thyroid hormone action is disrupted by bisphenol A as an antagonist.
Thyroid hormone action is disrupted by bisphenol A as an antagonist.
K. Moriyama,T. Tagami,7 Authors,K. Nakao
2002 · DOI: 10.1210/JC.2002-020209
Journal of Clinical Endocrinology and Metabolism · 825 Citations
TLDR
The results suggest that BPA could displace T(3) from the TR and recruit a transcriptional repressor, resulting in gene suppression, the first report that B PA can antagonize T( 3) action at the transcriptional level.