Thrombin Stimulates Human Endothelial Arginase Enzymatic Activity via RhoA/ROCK Pathway: Implications for Atherosclerotic Endothelial Dysfunction
Thrombin Stimulates Human Endothelial Arginase Enzymatic Activity via RhoA/ROCK Pathway: Implications for Atherosclerotic Endothelial Dysfunction
X. Ming,C. Barandiér,8 Authors,Zhihong Yang
2004 · DOI: 10.1161/01.CIR.0000142867.26182.32
Circulation · 253 Citations
TLDR
Higher arginase enzymatic activity is involved in atherosclerotic endothelial dysfunction in apoE−/− mice, and Targeting vascular arginases may represent a novel therapeutic possibility for atherosclerosis.