Three-dimensional cell migration does not follow a random walk
Three-dimensional cell migration does not follow a random walk
Pei-Hsun Wu,A. Giri,Sean X. Sun,D. Wirtz
2014 · DOI: 10.1073/pnas.1318967111
Proceedings of the National Academy of Sciences of the United States of America · 317 Citations
TLDR
This paper introduces and validate a new model of 3D cell migration that takes into account cell heterogeneity and the anisotropic movements induced by local remodeling of the 3D matrix, and reveals the unexpected robust relation between cell speed and persistence of migration over a wide range of matrix densities.