The role of heterogeneity of intersubunit interfaces in the outer membrane leaflet in maintaining GABAA receptor activity
The role of heterogeneity of intersubunit interfaces in the outer membrane leaflet in maintaining GABAA receptor activity
A. Rossokhin
2026 · DOI: 10.1007/s00249-026-01816-9
European Biophysics Journal · 0 Citações
TLDR
A new molecular mechanism for maintaining GABAAR in the activation state is proposed by constructing models of mutant GABAAR in which the Arg19′ side chain dynamics in the two above interface groups are opposite to those of wild-type receptor.