The regulation of aldosterone synthase expression.
The regulation of aldosterone synthase expression.
M. Bassett,P. White,W. Rainey
2004 · DOI: 10.1016/J.MCE.2003.10.011
Molecular and Cellular Endocrinology · 209 Citations
TLDR
Both potassium and angiotensin II (ANG II) increase intracellular calcium levels, which regulate expression of CYP11B2 through transcription factors that interact with defined sites in the 5'-flanking region of the gene.