The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers.
The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers.
Feng Li,Takeshi Hayashi,6 Authors,K. Abe
2005 · DOI: 10.1016/J.BRAINRES.2005.04.058
Brain Research · 71 Citations
TLDR
It is suggested that dantrolene significantly decreased infarct volume and provided neuroprotective effect on rats after transient MCAO by reducing ER stress-mediated apoptotic signal pathway activation in the ischemic area.