The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration
C. Lawson,K. Burridge
2014 · DOI: 10.4161/sgtp.27958
Small GTPases · 283 Citations
TLDR
This review focuses on RhoA and Rac1—2 Rho GTPases that are required for efficient adhesion and migration and describes how specific guanine nucleotide exchange factors and GTPase-activating proteins regulate the extensive crosstalk that exists between them.