The mystery of missing heritability: Genetic interactions create phantom heritability
The mystery of missing heritability: Genetic interactions create phantom heritability
O. Zuk,Eliana Hechter,S. Sunyaev,E. Lander
2012 · DOI: 10.1073/pnas.1119675109
Proceedings of the National Academy of Sciences of the United States of America · 1,585 Citations
TLDR
It is shown here that a substantial portion of missing heritability could arise from overestimation of the denominator, creating “phantom heritability,” and a method for estimating heritability from isolated populations that is not inflated by genetic interactions is described.