The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages
The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages
B. Gold,G. M. Rodríguez,2 Authors,I. Smith
2001 · DOI: 10.1046/j.1365-2958.2001.02684.x
Molecular Microbiology · 272 Citations
TLDR
Evidence that IdeR not only acts as a transcriptional repressor but also functions as an activator of bfrA is presented, demonstrating that iron‐dependent expression in Mycobacterium tuberculosis is regulated by an iron‐responsive DNA‐binding protein of the DtxR family.