The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence
The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence
María José Pérez,Alicia Lam,11 Authors,M. Deleidi
2026 · DOI: 10.1101/2024.09.03.610925
bioRxiv · 0 Citations
TLDR
How impaired mitochondrial proteostasis alters intercellular networks is revealed and a critical role for the UPRmt is identified in neurodegenerative disease pathogenesis is identified.