The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
F. Martinon,K. Burns,J. Tschopp
2002 · DOI: 10.1016/S1097-2765(02)00599-3
Molecules and Cells · 5,845 Citations
TLDR
It is shown that proinflammatory caspase activation and proIL-1beta processing is lost upon prior immunodepletion of Pycard, and the inflammasome constitutes an important arm of the innate immunity.