The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence
The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence
Jorge I Alvarez,A. Dodelet-Devillers,11 Authors,A. Prat
2011 · DOI: 10.1126/science.1206936
Science · 754 Citations
TLDR
It is shown that astrocytes secrete Sonic hedgehog and that BBB ECs express Hedgehog (Hh) receptors, which together promote BBB formation and integrity during embryonic development and adulthood.