The diverse neural crest: from embryology to human pathology

ABSTRACT We review here some of the historical highlights in exploratory studies of the vertebrate embryonic structure known as the neural crest. The study of the molecular properties of the cells that it produces, their migratory capacities and plasticity, and the still-growing list of tissues that depend on their presence for form and function, continue to enrich our understanding of congenital malformations, paediatric cancers and evolutionary biology. Developmental biology has been key to our understanding of the neural crest, starting with the early days of experimental embryology and through to today, when increasingly powerful technologies contribute to further insight into this fascinating vertebrate cell population. Summary: This Primer reviews how exploratory studies of the vertebrate embryonic structure known as the neural crest contribute to enrich our understanding of cancers and congenital malformations.