The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.
The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.
G. Kaiko,Stacy H Ryu,6 Authors,T. Stappenbeck
2016 · DOI: 10.1016/j.cell.2016.05.018
Cell · 565 Citations
TLDR
It is indicated that mammalian crypt architecture protects stem/progenitor cell proliferation in part through a metabolic barrier formed by differentiated colonocytes that consume butyrate and stimulate future studies on the interplay of host anatomy and microbiome metabolism.