The bile acid sensor FXR regulates insulin transcription and secretion.
The bile acid sensor FXR regulates insulin transcription and secretion.
B. Renga,A. Mencarelli,2 Authors,S. Fiorucci
2010 · DOI: 10.1016/j.bbadis.2010.01.002
Biochimica et Biophysica Acta · 181 Citations
TLDR
In vivo experiments on NOD mice demonstrated that FXR activation delays development of signs of diabetes, hyperglycemia and glycosuria, by enhancing insulin secretion and by stimulating glucose uptake by the liver, established that an FXR-KLF11 regulated pathway has an essential role in the regulation of insulin transcription and secretion induced by glucose.