The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
Thorsten E. Boroviak,R. Loos,2 Authors,J. Nichols
2014 · DOI: 10.1038/ncb2965
Nature Cell Biology · 433 Citations
TLDR
It is suggested that formation of the epiblast coincides with competence for ERK-independent self-renewal in vitro and consequent propagation as ESC lines and that ICM cells from early blastocysts can progress to ERK independence if provided with a specific laminin substrate.