Thalamic and extrathalamic mechanisms of consciousness after severe brain injury
Thalamic and extrathalamic mechanisms of consciousness after severe brain injury
E. Lutkenhoff,J. Chiang,6 Authors,M. Monti
TLDR
This largest cohort of patients with disorders of consciousness to date sought to establish the link between gold standard clinical measures of awareness and wakefulness, and specific patterns of local brain pathology, possibly providing a mechanistic framework for patient diagnosis, prognosis, and treatment development.
Abstract
What mechanisms underlie the loss and recovery of consciousness after severe brain injury? We sought to establish, in the largest cohort of patients with disorders of consciousness (DOC) to date, the link between gold standard clinical measures of awareness and wakefulness, and specific patterns of local brain pathology—thereby possibly providing a mechanistic framework for patient diagnosis, prognosis, and treatment development.