Tensional homeostasis and the malignant phenotype.
Tensional homeostasis and the malignant phenotype.
M. Paszek,Nastaran Zahir,9 Authors,V. Weaver
2005 · DOI: 10.1016/J.CCR.2005.08.010
Cancer Cell · 3,939 Citations
TLDR
It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.