Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
Jingwei Zheng,Haijian Wu,11 Authors,Jun Yu
2023 · DOI: 10.1016/j.jpha.2023.02.007
Journal of Pharmaceutical Analysis · 29 Citations
TLDR
ST analysis indicated that microglia-derived insulin like growth factor 1 (IGF1) modulated astrocytic scar formation via mechanistic target of rapamycin (mTOR) signaling activation, and repopulating microglial (RM) more strongly activated mTOR signaling, facilitating a more protective scar formation.