Targeting renal fibrosis: Mechanisms and drug delivery systems
Targeting renal fibrosis: Mechanisms and drug delivery systems
M. Nastase,Jinyang Zeng-Brouwers,M. Wygrecka,L. Schaefer
2017 · DOI: 10.1016/j.addr.2017.12.019
Advanced Drug Delivery Reviews · 246 Citations
TLDR
Mechanisms of renal fibrosis and methods of drug transfer into the kidney are described and an intriguing new method to deliver drugs specifically to tubular epithelial cells via conjugation with ligands binding to the megalin receptor is assessed.