Targeting leukemia-specific dependence on the de novo purine synthesis pathway
Targeting leukemia-specific dependence on the de novo purine synthesis pathway
T. Yamauchi,K. Miyawaki,11 Authors,Takahiro Maeda
2021 · DOI: 10.1038/s41375-021-01369-0
Leukemia · 16 Citations
TLDR
It is shown that PAICS, an enzyme involved in de noovo purine biosynthesis, is a potential target for AML therapy and components of de novo purine synthesis pathway and its downstream effectors essential for AMl cell survival are defined.