Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
Marsha C. Lampi,Cynthia A. Reinhart-King
2018 · DOI: 10.1126/scitranslmed.aao0475
Science Translational Medicine · 466 Citations
TLDR
Therapeutic interventions that target tissue stiffening are discussed in the context of their limitations, preclinical drug development efforts, and clinical trials.