Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
J. Ruschel,F. Hellal,15 Authors,F. Bradke
2015 · DOI: 10.1126/science.aaa2958
Science · 342 Citations
TLDR
Delayed systemic administration of a blood-brain barrier–permeable microtubule-stabilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) and promoted axon regeneration and improved motor function after SCI.