Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin
Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin
Heather L. Cash,Cecilia V Whitham,Cassie L. Behrendt,L. Hooper
2006 · DOI: 10.1126/science.1127119
Science · 1,427 Citations
TLDR
It is proposed that RegIIIγ and its human counterpart, HIP/PAP, are directly antimicrobial proteins that bind their bacterial targets via interactions with peptidoglycan carbohydrate, and that they reveal intestinal strategies for maintaining symbiotic host-microbial relationships.