Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.
Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.
K. Karikó,M. Buckstein,Houping Ni,D. Weissman
2005 · DOI: 10.1016/J.IMMUNI.2005.06.008
Immunity · 2,138 Citations
TLDR
It is concluded that nucleoside modifications suppress the potential of RNA to activate DCs, and the innate immune system may detect RNA lacking nucleosides modification as a means of selectively responding to bacteria or necrotic tissue.