Sugammadex-induced bradycardia and asystole: how great is the risk?

The investigators found that the timescale is a function of noise, with noisier systems associated with a shorter collapse time for hysteresis and anaesthetic state transitions, and the extension of the Markov process to 10 states explains the shallower and left-shifted doseeresponse curve for emergence relative to induction and the large variability of emergence.