Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.
Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.
B. Carpenter,G. R. Hemsworth,4 Authors,P. Artymiuk
2012 · DOI: 10.1016/j.str.2012.01.019
Structure · 73 Citations
TLDR
A molecular model of the putative leptin-LBD complex reveals that 9F8 Fab blocks leptin binding through only a small overlap in their binding sites, and that leptin binding is likely to involve an induced fit mechanism.