Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes
Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes
V. Delfosse,M. Grimaldi,6 Authors,P. Balaguer
2012 · DOI: 10.1073/pnas.1203574109
Proceedings of the National Academy of Sciences of the United States of America · 354 Citations
TLDR
The mechanisms by which BPA and two congeners bind to and activate estrogen receptors (ER) α and β differ from that used by 17β-estradiol, providing a wealth of tools and information that could be used for the development of BPA substitutes devoid of nuclear hormone receptor-mediated activity and more generally for environmental risk assessment.