Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO.
Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO.
H. Chagraoui,M. Tulliez,6 Authors,F. Wendling
2003 · DOI: 10.1182/BLOOD-2002-09-2839
Blood · 91 Citations
TLDR
It is suggested that osteosclerosis in mice with TPO overexpression occurs predominantly via an up-regulation of OPG in host stromal cells leading to disruption of osteoclastogenesis.