Statins improve NASH via inhibition of RhoA and Ras.
Statins improve NASH via inhibition of RhoA and Ras.
R. Schierwagen,L. Maybüchen,12 Authors,J. Trebicka
2016 · DOI: 10.1152/ajpgi.00063.2016
70 Citations
TLDR
Investigation of the molecular mechanisms underlying pleiotropic effects on small GTPases of statins in NASH found inhibition of RhoA and Ras downstream signaling by statins is responsible for the beneficial hepatic effects in NASh.