SMART, a simple modular architecture research tool: identification of signaling domains.
SMART, a simple modular architecture research tool: identification of signaling domains.
J. Schultz,F. Milpetz,P. Bork,C. Ponting
1998 · DOI: 10.1073/PNAS.95.11.5857
Proceedings of the National Academy of Sciences of the United States of America · 3,701 Citations
TLDR
Accurate multiple alignments of 86 domains that occur in signaling proteins have been constructed and used to provide a Web-based tool that allows rapid identification and annotation of signaling domain sequences, showing that at least 6.7% of yeast genes contain one or more signaling domains, approximately 350 greater than previously annotated.