Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells
Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells
Ishaan Gupta,Paul G Collier,13 Authors,Hagen U. Tilgner
2018 · DOI: 10.1038/nbt.4259
Nature Biotechnology · 294 Citations
TLDR
Using single-cell isoform RNA-Seq (ScISOr-Sequ), RNA isoforms in neurons, astrocytes, microglia, and cell subtypes such as Purkinje and Granule cells are identified and cell-type-specific combination patterns of distant splice sites are identified.