Sequence kernel association tests for the combined effect of rare and common variants.
Sequence kernel association tests for the combined effect of rare and common variants.
I. Ionita-Laza,Seunggeun Lee,2 Authors,Xihong Lin
2013 · DOI: 10.1016/j.ajhg.2013.04.015
American Journal of Human Genetics · 443 Citations
TLDR
Several sequence kernel association tests are introduced to evaluate the cumulative effect of rare and common variants and can achieve substantial increases in power compared with the most commonly used tests, including the burden and variance-component tests.