Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group.
Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group.
T. Kinney,R. Helms,8 Authors,R. Ware
1999 · DOI: 10.1182/BLOOD.V94.5.1550.417K13_1550_1554
Blood · 499 Citations
TLDR
This Phase I/II trial shows that HU therapy is safe for children with sickle cell anemia when treatment was directed by a pediatric hematologist and no life-threatening clinical adverse events occurred and no child experienced growth failure.