RTCDB: A Multi-Omics Database Supporting Research and Discovery in Rare Tumor Oncology

Rare tumors are generally faced with the dilemma of delayed diagnosis, lack of treatment methods and poor prognosis due to their high clinical heterogeneity, low incidence but numerous subtypes. Although the analysis of molecular mechanisms and clinical characteristics is crucial to improving the clinical research of rare tumors, current research is limited by the scattered heterogeneity of multi-center data, scarce sample size and lack of standardized integration mechanism, which seriously hinders the process of basic research to clinical transformation. In order to meet such challenges, we are committed to building a rare tumor comprehensive database website. The core goal of this platform is to aggregate and provide high-quality and reliable datasets (including genome, transcriptome, proteome and clinical information) of various rare tumor types, providing a centralized and efficient resource center for researchers around the world, thereby accelerating the basic research and clinical transformation exploration of rare tumors. The database website (RTCDB) contains $\mathbf{1 3 4}$ rare tumor types and 306 selected datasets with 7912 samples. The establishment of this rare tumor database will strongly promote the collaborative cooperation and rapid development of related research. RTCDB can be accessed for free at http://www.rtedb.cn/.