rs5848 polymorphism and serum progranulin level

The rs5848 SNP significantly influenced serum PGRN level, with TT genotype having the lowest levels, and CC as the highest, which is consistent with the finding that miR-659 binding to the high risk T allele ofrs5848 may augment translational inhibition of GRN and alter risk of FTD and possibly other dementias.