Role of Three-Dimensional Matrix Stiffness in Regulating the Response of Human Neural Cells to Toxins
Role of Three-Dimensional Matrix Stiffness in Regulating the Response of Human Neural Cells to Toxins
Kalpith Ramamoorthi,Jared H. Hara,C. Ito,Prashanth Asuri
2014 · DOI: 10.1007/S12195-014-0326-Y
16 Citations
TLDR
A strong role of mechanotransductive signaling on the response of neural cells to toxins is suggested and determining the role of substrate stiffness on the toxic response of Neural cells will be crucial to the development of optimal in vitro cell-based screens of neurotoxicity.