Role of antigen-presenting cells in activation of human T cells by the streptococcal M protein superantigen: requirement for secreted and membrane-associated costimulatory factors
Role of antigen-presenting cells in activation of human T cells by the streptococcal M protein superantigen: requirement for secreted and membrane-associated costimulatory factors
G. Majumdar,Hiroaki Ohnishi,5 Authors,Malak KOTBl
1993 · DOI: 10.1128/iai.61.2.785-790.1993
Infection and Immunity · 5 Citations
TLDR
The data suggest that pep M5-induced activation of T cells is dependent on APC-derived soluble factors and an APC membrane-associated costimulatory molecule(s), which may be important in regulating the in vivo responses to M proteins, and could contribute to the severity or progression of infections with Streptococcus pyogenes.