Rifampicin has no role in treatment of Mycobacterium avium complex pulmonary disease and bactericidal sterilising drugs are needed: a viewpoint

Extract Current rifampicin/ethambutol/azithromycin regimens for the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) are long, toxic and yield relatively poor outcomes [1]: a meta-analysis lumping nodular bronchiectatic disease and fibro-cavitary disease reported a 65% prolonged culture conversion rate; following initially successful treatment, recurrence rates of 30% have been reported [2]. Shareable abstract Rifampicin is used for the treatment of Mycobacterium avium complex pulmonary disease, but pharmacokinetic and pharmacodynamic studies suggest that rifampicin cannot have therapeutic utility. We need to find better alternatives, using PK-PD science. https://bit.ly/3PUGvbV