Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
F. Baenke,B. Chaneton,10 Authors,R. Marais
2015 · DOI: 10.1016/j.molonc.2015.08.003
Molecular Oncology · 155 Citations
TLDR
It is shown that BRAF mutant melanoma cells that have developed acquired resistance to BRAF inhibitors display increased oxidative metabolism and increased dependency on mitochondria for survival, suggesting that targeting specific metabolic pathways may offer exciting therapeutic opportunities to treat resistant tumors, or to delay emergence of resistance in the first‐line setting.