Release of protein A from the cell wall of Staphylococcus aureus
Release of protein A from the cell wall of Staphylococcus aureus
Samuel Becker,M. Frankel,O. Schneewind,D. Missiakas
2014 · DOI: 10.1073/pnas.1317181111
Proceedings of the National Academy of Sciences of the United States of America · 140 Citations
TLDR
It is demonstrated that protein A of Staphylococcus aureus, a B cell superantigen, is released with peptidoglycan linked to its C terminus, and a model is proposed whereby murein hydrolases cleave the anchor structure of released SpA to modify host immune responses.