Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.
Carole L Wilson,A. J. Ouellette,6 Authors,William C. Parks
1999 · DOI: 10.1126/SCIENCE.286.5437.113
Science · 1,133 Citations
TLDR
Matrilysin functions in intestinal mucosal defense by regulating the activity of defensins, which may be a common role for this metalloproteinase in its numerous epithelial sites of expression.