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Rationale and Design of the Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure

Alexander J. Blood,Ozan Unlu,14 Authors,Benjamin M. Scirica

2026 · DOI: 10.1002/clc.70222
Clinical Cardiology · 1 Citations

TLDR

Despite overwhelming evidence of clinical benefit for patients with heart failure, the uptake of guideline‐directed medical therapies has been slow and most existing approaches focus primarily on patients with HF and reduced EF, despite growing evidence for effective pharmacologic therapy.

Abstract

Despite overwhelming evidence of clinical benefit for patients with heart failure (HF), the uptake of guideline‐directed medical therapies (GDMT) has been slow. Collaborative approaches are critically needed to improve alignment between evidence and clinical practice. Many strategies proposed to improve GDMT implementation have been either ineffective or too resource‐intensive to implement at scale across different practice contexts. Furthermore, most existing approaches focus primarily on patients with HF and reduced EF, despite growing evidence for effective pharmacologic therapy in those with HF and mildly reduced or preserved ejection fraction (HFpEF).