Rac activation and inactivation control plasticity of tumor cell movement.
Rac activation and inactivation control plasticity of tumor cell movement.
Victoria Sanz‐Moreno,Gilles Gadea,5 Authors,C. Marshall
2008 · DOI: 10.1016/j.cell.2008.09.043
Cell · 989 Citations
TLDR
It is shown that mesenchymal-type movement in melanoma cells is driven by activation of the GTPase Rac through a complex containing NEDD9, a recently identified melanoma metastasis gene, and DOCK3, a Rac guanine nucleotide exchange factor.