Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
J. Kowal,Guillaume Arras,7 Authors,C. Théry
2016 · DOI: 10.1073/pnas.1521230113
Proceedings of the National Academy of Sciences of the United States of America · 2,903 Citations
TLDR
This work demonstrates the presence of exosomal and nonexosomal subpopulations within small EVs, and proposes their differential separation by immuno-isolation using either CD63, CD81, or CD9, and provides guidelines to define subtypes of EVs for future functional studies.