Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.
K. Uysal,S. Wiesbrock,M. Marino,G. Hotamisligil
1997
Nature · 1,072 Citations
TLDR
Results indicate that TNF-alpha is an important mediator of insulin resistance in obesity through its effects on several important sites of insulin action.